Isoleucine and Valine Metabolism in Escherichia coli XIX. Inhibition of Isoleucine Biosynthesis by Glycyl-Leucine
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چکیده
منابع مشابه
Glycyl dehydropeptides of leucine, valine, and isoleucine.
Glycyl dehydropeptides of alanine, phenylalanine, norvaline, norleucine, and or-aminobutyric acid, and N-acetyl dehydropeptides of these amino acids, tyrosine, valine, and leucine have been prepared (l-3). Although the glycyl dehydropeptides were found to be hydrolyzed by tissue extracts, the only enzymatically susceptible N-acetyl dehydropeptide was that of alanine (1). In an effort to acquire...
متن کاملIsoleucine and Valine Metabolism of Escherichia Coli
In the preceding publication (1) mention has been made of the syntrophism existing between the mutant strains llA16 and 2OA19 of Escherichia COG. These mutants, requiring isoleucine and isoleucine plus valine respectively, were able to grow together on a minimal agar plate, free of amino acids, which would not support the growth of either mutant alone. The nature of this syntrophism forms the s...
متن کاملIsoleucine and valine metabolism in Escherichia coli. V. Antagonism between isoleucine and valine.
The influence of the relative concentrations of amino acids in culture media on the growth of microorganisms was first brought to the attention of microbiologists by Gladstone (1939). He observed that isoleucine, valine, or leucine added singly to a synthetic medium inhibited the growth of the anthrax bacillus whereas a mixture of the three stimulated growth. Although Gladstone was unable at th...
متن کاملIsoleucine and Valine Metabolism in Escherichia coZi
On the basis of isotopic results obtained with Torulopsis utilis and Neurospora crassa, Strassman et al. (1) and Adelberg (2) have proposed a mechanism for valine biosynthesis in which pyruvate is converted to a-acetolactate. Acetolactate would then undergo a rearrangement to yield the carbon skeleton of valine. Abelson (3) showed that pyruvate, in competition with glucose, gave rise to the car...
متن کاملBiosynthesis of Valine and Isoleucine
The isotope studies of Strassman et al. (3, 4) first implicated cu-acetolactate and cu-aceto-cY-hydroxybutyrate as biosynthetic precursors of valine and isoleucine, respectively. The observed accumulation of acetolactate by Escherichia coli (5, 6) and of the decarboxylation products of acetolactate and acetohydroxybutyrate by Neurospora crassa (7) when mutants of these organisms are grown with ...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1972
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.112.1.142-147.1972